Metabolomics in drug research and development: The recent advances in technologies and applications.
10.1016/j.apsb.2023.05.021
- Author:
Huanhuan PANG
1
;
Zeping HU
1
Author Information
1. School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing 100084, China.
- Publication Type:Review
- Keywords:
Drug research and development;
Drug response;
Drug target;
Metabolomics;
Mode of action of drug;
Personalized treatment;
Technology
- From:
Acta Pharmaceutica Sinica B
2023;13(8):3238-3251
- CountryChina
- Language:English
-
Abstract:
Emerging evidence has demonstrated the vital role of metabolism in various diseases or disorders. Metabolomics provides a comprehensive understanding of metabolism in biological systems. With advanced analytical techniques, metabolomics exhibits unprecedented significant value in basic drug research, including understanding disease mechanisms, identifying drug targets, and elucidating the mode of action of drugs. More importantly, metabolomics greatly accelerates the drug development process by predicting pharmacokinetics, pharmacodynamics, and drug response. In addition, metabolomics facilitates the exploration of drug repurposing and drug-drug interactions, as well as the development of personalized treatment strategies. Here, we briefly review the recent advances in technologies in metabolomics and update our knowledge of the applications of metabolomics in drug research and development.
