Therapeutic potential of NADH: in neurodegenerative diseases characterizde by mitochondrial dysfunction.
10.13201/j.issn.2096-7993.2024.01.009
- Author:
Ziyi CHEN
1
;
Hongyang WANG
1
;
Qiuju WANG
1
Author Information
1. Department of Audiology and Vestibular Medicine，Institute of Otolaryngology，Senior Department of Otolaryngology Head and Neck Surgery，the Sixth Medical Center of Chinese PLA General Hospital，National Clinical Research Center for Otolaryngologic Diseases，Beijing，100048，China.
- Publication Type:Journal Article
- Keywords:
mitochondrial dysfunction;
neurodegenerative diseases;
nicotinamide adenine dinucleotide
- MeSH:
Humans;
NAD/metabolism*;
Neurodegenerative Diseases/metabolism*;
Mitochondria;
Oxidation-Reduction;
Mitochondrial Diseases
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2024;38(1):57-62
- CountryChina
- Language:Chinese
-
Abstract:
Nicotinamide adenine dinucleotide（NADH） in its reduced form of is a key coenzyme in redox reactions, essential for maintaining energy homeostasis.NADH and its oxidized counterpart, NAD+, form a redox couple that regulates various biological processes, including calcium homeostasis, synaptic plasticity, anti-apoptosis, and gene expression. The reduction of NAD+/NADH levels is closely linked to mitochondrial dysfunction, which plays a pivotal role in the cascade of various neurodegenerative disorders, including Parkinson's disease and Alzheimer's disease.Auditory neuropathy（AN） is recognized as a clinical biomarker in neurodegenerative disorders. Furthermore, mitochondrial dysfunction has been identified in patients with mutations in genes like OPA1and AIFM1. However, effective treatments for these conditions are still lacking. Increasing evidence suggests that administratering NAD+ or its precursors endogenously may potentially prevent and slow disease progression by enhancing DNA repair and improving mitochondrial function. Therefore, this review concentrates on the metabolic pathways of NAD+/NADH production and their biological functions, and delves into the therapeutic potential and mechanisms of NADH in treating AN.
