Differential expression of NEDD8 in different pathological types of chronic rhinosinusitis with nasal polyps.
10.13201/j.issn.2096-7993.2023.11.008
- Author:
Chen MENG
1
;
Bing YAN
1
;
Yuqing HUANG
1
;
Chengshuo WANG
1
;
Luo ZHANG
1
Author Information
1. Department of Otolaryngology，Head and Neck Surgery，Beijing TongRen Hospital，Capital Medical University，Beijing，100730，China.
- Publication Type:Journal Article
- Keywords:
eosinophils;
nasal polyps;
neural precursor cell-expressed developmentally downregulated 8;
rhinosinusitis
- MeSH:
Humans;
Nasal Polyps/metabolism*;
Rhinitis/diagnosis*;
NEDD8 Protein/metabolism*;
Sinusitis/diagnosis*;
Eosinophils/metabolism*;
Chronic Disease
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2023;37(11):897-901
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the differential expression of neural precursor cell-expressed developmentally downregulated 8（NEDD8） protein in nasal polyp tissues of patients with different pathological types of chronic rhinorhinosinusitis with nasal polyps（CRSwNP）. Methods:All specimens were obtained from the specimen library of Beijing Tongren Hospital, and were all patients who underwent nasal endoscopic surgery for chronic rhinosinusitis in Beijing Tongren Hospital. Hematoxylin-eosin staining（HE） was used to detect the number of eosinophils in nasal polyps, and CRSwNP patients were grouped according to the number of eosinophils in nasal polyps, immunohistochemistry was used to detect and analyze the expression level of NEDD8 protein in nasal polyps. Results:The expression level of NEDD8 protein in nasal polyps of patients with eosinophilic chronic rhinorhinosinusitis with nasal polyps was significantly higher than that of patients with non-eosinophilic chronic rhinosinusitis and nasal polyps（P<0.05）. In addition, there was a significant positive correlation between the expression level of NEDD8 protein and the number of eosinophils in nasal polyp tissue（r=0.79, P=0.02）. Conclusion:There are differences in the expression of NEDD8 protein in patients with chronic rhinosinusitis and nasal polyps of different pathological types.
