Polysaccharides from Chinese herbal medicine: a review on the hepatoprotective and molecular mechanism.
10.1016/S1875-5364(24)60558-3
- Author:
Jifeng LI
1
;
Haolin GUO
1
;
Ying DONG
1
;
Shuo YUAN
2
;
Xiaotong WEI
1
;
Yuxin ZHANG
1
;
Lu DONG
1
;
Fei WANG
1
;
Ting BAI
3
;
Yong YANG
4
Author Information
1. Dalian Key Laboratory of Chronic Disease Research Center, Dalian University, Dalian 116622, China.
2. Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China.
3. Dalian Key Laboratory of Chronic Disease Research Center, Dalian University, Dalian 116622, China. Electronic address: baiting@dlu.edu.cn.
4. Dalian Key Laboratory of Chronic Disease Research Center, Dalian University, Dalian 116622, China. Electronic address: yangyong@dlu.edu.cn.
- Publication Type:Review
- Keywords:
Chinese herbal medicine;
Hepatoprotective;
Mechanism;
Polysaccharides
- MeSH:
Humans;
Drugs, Chinese Herbal/pharmacology*;
Liver Diseases/drug therapy*;
Antioxidants;
Polysaccharides/therapeutic use*;
Medicine, Chinese Traditional
- From:
Chinese Journal of Natural Medicines (English Ed.)
2024;22(1):4-14
- CountryChina
- Language:English
-
Abstract:
Polysaccharides, predominantly extracted from traditional Chinese medicinal herbs such as Lycium barbarum, Angelica sinensis, Astragalus membranaceus, Dendrobium officinale, Ganoderma lucidum, and Poria cocos, represent principal bioactive constituents extensively utilized in Chinese medicine. These compounds have demonstrated significant anti-inflammatory capabilities, especially anti-liver injury activities, while exhibiting minimal adverse effects. This review summarized recent studies to elucidate the hepatoprotective efficacy and underlying molecular mechanisms of these herbal polysaccharides. It underscored the role of these polysaccharides in regulating hepatic function, enhancing immunological responses, and improving antioxidant capacities, thus contributing to the attenuation of hepatocyte apoptosis and liver protection. Analyses of molecular pathways in these studies revealed the intricate and indispensable functions of traditional Chinese herbal polysaccharides in liver injury management. Therefore, this review provides a thorough examination of the hepatoprotective attributes and molecular mechanisms of these medicinal polysaccharides, thereby offering valuable insights for the advancement of polysaccharide-based therapeutic research and their potential clinical applications in liver disease treatment.
