A review of structural modification and biological activities of oleanolic acid.
10.1016/S1875-5364(24)60559-5
- Author:
Huali YANG
1
,
2
;
Minghui DENG
3
;
Hongwei JIA
3
;
Kaicheng ZHANG
3
;
Yang LIU
3
;
Maosheng CHENG
4
;
Wei XIAO
5
Author Information
1. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
3. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
4. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: mscheng@syphu.edu.cn.
5. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China. Electronic address: xw_kanion@163.com.
- Publication Type:Review
- Keywords:
Biological activities.;
Derivatives;
Oleanolic acid;
Pentacyclic triterpenoid;
Structural modification
- MeSH:
Oleanolic Acid;
Structure-Activity Relationship;
Anti-Inflammatory Agents/pharmacology*;
Triterpenes;
Anti-Bacterial Agents/pharmacology*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2024;22(1):15-30
- CountryChina
- Language:English
-
Abstract:
Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits a broad spectrum of biological activities, including antitumor, antiviral, antibacterial, anti-inflammatory, hepatoprotective, hypoglycemic, and hypolipidemic effects. Since its initial isolation and identification, numerous studies have reported on the structural modifications and pharmacological activities of OA and its derivatives. Despite this, there has been a dearth of comprehensive reviews in the past two decades, leading to challenges in subsequent research on OA. Based on the main biological activities of OA, this paper comprehensively summarized the modification strategies and structure-activity relationships (SARs) of OA and its derivatives to provide valuable reference for future investigations into OA.
