Abietane diterpenoids and iridoids from Caryopteris mongolica.
10.1016/S1875-5364(23)60409-1
- Author:
Shanshan ZHANG
1
;
Xudong MAO
2
;
Hongtao XU
3
;
Xiaohui WEI
4
;
Guixin CHOU
5
,
6
Author Information
1. Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
2. State Key Lab of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
3. Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China.
4. Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: xht8710@163.com.
5. Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
6. Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China. Electronic address: chouguixin@shutcm.edu.cn.
- Publication Type:Journal Article
- Keywords:
Abietane diterpenoids;
Caryopteris mongolica;
Cytotoxicity;
Spectroscopic analysis
- MeSH:
Humans;
Abietanes/chemistry*;
HeLa Cells;
Lamiaceae/chemistry*;
Circular Dichroism;
Diterpenes/chemistry*;
Molecular Structure
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(12):927-937
- CountryChina
- Language:English
-
Abstract:
Six new abietane diterpenoids (1-6) and five undescribed iridoids (7-11) have been isolated from the aerial parts of Caryopteris mongolica. The intricate structural characterization of these compounds was meticulously undertaken using an array of advanced spectroscopic techniques. This process was further enhanced by the application of DP4+ probability analyses and electronic circular dichroism (ECD) calculations. Following isolation and structural elucidation, the cytotoxicity of these compounds was evaluated. Among them, compound 3 stood out, displaying significant cytotoxic activity against HeLa cells with an IC50 value of 7.83 ± 1.28 μmol·L-1. Additionally, compounds 1, 2, 4, 9, and 10 manifested moderate cytotoxic effects on specific cell lines, with IC50 values ranging from 11.7 to 20.9 μmol·L-1.
