Thirteen new peptaibols with antimicrobial activities from Trichoderma sp.
10.1016/S1875-5364(23)60499-6
- Author:
Pan TANG
1
;
Dan HUANG
1
;
Kai-Xuan ZHENG
1
;
Dan HU
1
;
Ping DAI
1
;
Chuan-Hui LI
1
;
Sheng-Ying QIN
2
;
Guo-Dong CHEN
3
;
Xin-Sheng YAO
1
;
Hao GAO
4
Author Information
1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou 510632, China.
2. Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
3. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou 510632, China. Electronic address: chgdtong@163.com.
4. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou 510632, China. Electronic address: tghao@jnu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Antibacterial activity;
Harzianin;
Neoatroviridin;
Peptaibols;
Trichoderma sp.
- MeSH:
Peptaibols/chemistry*;
Trichoderma/metabolism*;
Tandem Mass Spectrometry/methods*;
Anti-Infective Agents/pharmacology*;
Spectrometry, Mass, Electrospray Ionization/methods*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(11):868-880
- CountryChina
- Language:English
-
Abstract:
From the fungus Trichoderma sp., we isolated seven novel 18-residue peptaibols, neoatroviridins E-K (1-7), and six new 14-residue peptaibols, harzianins NPDG J-O (8-13). Additionally, four previously characterized 18-residue peptaibols neoatroviridins A-D (14-17) were also identified. The structural configurations of the newly identified peptaibols (1-13) were determined by comprehensive nuclear magnetic resonance (NMR) and high-resolution electrospray ionization tandem mass spectrometry (HR-ESI-MS/MS) data. Their absolute configurations were further determined using Marfey's method. Notably, compounds 12 and 13 represent the first 14-residue peptaibols containing an acidic amino acid residue. In antimicrobial assessments, all 18-residue peptaibols (1-7, 14-17) exhibited moderate inhibitory activities against Staphylococcus aureus 209P, with minimum inhibitory concentration (MIC) values ranging from 8-32 μg·mL-1. Moreover, compound 9 exhibited moderate inhibitory effect on Candida albicans FIM709, with a MIC value of 16 μg·mL-1.
