Six new coumarins from the roots of Toddalia asiatica and their anti-inflammatory activities.
10.1016/S1875-5364(23)60480-7
- Author:
Haoxuan HE
1
;
Niping LI
2
;
Yunqi FAN
1
;
Qian HUANG
2
;
Jianguo SONG
2
;
Lixia LV
1
;
Fen LIU
2
;
Lei WANG
2
;
Qi WANG
3
;
Jihong GU
4
Author Information
1. Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
2. State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, China.
3. Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. Electronic address: wangqi@gzucm.edu.cn.
4. Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. Electronic address: gujh@gzcum.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory effects;
Coumarins;
RAW 264.7 cells;
Toddalia asiatica
- MeSH:
Mice;
Animals;
Coumarins/chemistry*;
Rutaceae/chemistry*;
Anti-Inflammatory Agents/pharmacology*;
Plant Extracts/chemistry*;
RAW 264.7 Cells;
Nitric Oxide;
Molecular Structure
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(11):852-858
- CountryChina
- Language:English
-
Abstract:
We reported the discovery of six novel coumarins, toddasirins A-F (1-6), each endowed with modified isoprenyl or geranyl side chains, derived from the roots of Toddalia asiatica. Comprehensive structural elucidation was achieved through multispectroscopic analyses, single-crystal X-ray diffraction experiments, and advanced quantum mechanical electronic circular dichroism (ECD) calculations. Furthermore, the anti-inflammatory activity of these compounds was assessed. Notably, compounds 1-3 and 6 demonstrated notable inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells, with 50% inhibitory concentration (IC50) values of 3.22, 4.78, 8.90, and 4.31 μmol·L-1, respectively.
