Anti-hepatitis B virus activities of natural products and their antiviral mechanisms.
10.1016/S1875-5364(23)60505-9
- Author:
Wanyu DENG
1
;
Fu CHEN
1
;
Yue ZHAO
2
;
Ming ZHOU
3
,
4
,
5
;
Min GUO
6
Author Information
1. College of Life Science, Shangrao Normal University, Shangrao 334001, China.
2. State Key Laboratory of Natural Medicines, School of Life Science&Technology, China Pharmaceutical University, Nanjing 211198, China.
3. BGI-Shenzhen, Shenzhen 518000, China
4. Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518110, China
5. Liver-biotechnology (Shenzhen) Co., Ltd., Shenzhen 518110, China. Electronic address: zhouming2004@126.com.
6. State Key Laboratory of Natural Medicines, School of Life Science&Technology, China Pharmaceutical University, Nanjing 211198, China. Electronic address: 1020152471@cpu.edu.cn.
- Publication Type:Review
- Keywords:
Antiviral stategy;
Hepatitis B virus;
Host hepatocyte;
Life cycle;
Mechanisms;
Natural products
- MeSH:
Humans;
Hepatitis B virus;
Hepatitis B, Chronic/drug therapy*;
Antiviral Agents/therapeutic use*;
Biological Products/therapeutic use*;
Hepatocytes
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(11):803-811
- CountryChina
- Language:English
-
Abstract:
Chronic hepatitis B (CHB) infections caused by the hepatitis B virus (HBV) continue to pose a significant global public health challenge. Currently, the approved treatments for CHB are limited to interferon and nucleos(t)ide analogs, both of which have their limitations, and achieving a complete cure remains an elusive goal. Therefore, the identification of new therapeutic targets and the development of novel antiviral strategies are of utmost importance. Natural products (NPs) constitute a class of substances known for their diverse chemical structures, wide-ranging biological activities, and low toxicity profiles. They have shown promise as potential candidates for combating various diseases, with a substantial number demonstrating anti-HBV properties. This comprehensive review focuses on the current applications of NPs in the fight against HBV and provides a summary of their antiviral mechanisms, considering their impact on the viral life cycle and host hepatocytes. By offering insights into the world of anti-HBV NPs, this review aims to furnish valuable information to support the future development of antiviral drugs.
