Steroid and triterpenoid saponins from the rhizomes of Paris polyphylla var. stenophylla.
10.1016/S1875-5364(23)60486-8
- Author:
Jinming HU
1
;
Yunyang LU
1
;
Shuxian ZHENG
1
;
Yunyuan TIAN
1
;
Tianyi LI
1
;
Haifeng TANG
2
;
Zhao YANG
3
;
Yang LIU
4
Author Information
1. Department of Chinese Medical and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an 710032, China.
2. Department of Chinese Medical and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an 710032, China. Electronic address: tanghaifeng71@163.com.
3. Department of Military Medical Psychology, Air Force Military Medical University, Xi'an 710032, China. Electronic address: yangzhaofirst@126.com.
4. Department of Chinese Medical and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an 710032, China. Electronic address: so870823@163.com.
- Publication Type:Journal Article
- Keywords:
Cyclocholestanol-type;
Paris polyphylla var. stenophylla;
Steroid saponins;
Triterpenoid saponins
- MeSH:
Humans;
Rhizome/chemistry*;
Steroids/chemistry*;
Liliaceae/chemistry*;
Saponins/chemistry*;
Triterpenes/analysis*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(10):789-800
- CountryChina
- Language:English
-
Abstract:
Five new saponins, including three steroid saponins, paristenoids A-C (1-3), and two triterpenoid saponins, paristenoids D-E (4-5), along with four known ones (6-9) were isolated from the rhizomes of Paris polyphylla var. stenophylla. The structures of the isolated compounds were identified mainly by detailed spectroscopic analysis, including extensive 1D and 2D NMR, MS, as well as chemical methods. Compound 3 is a new cyclocholestanol-type steroidal saponin with a rare 6/6/6/5/5 fused-rings cholestanol skeleton, and this skeleton has been first found from the genus Paris. The cytotoxicities of the isolated compounds against three human three glioma cell lines (U87MG, U251MG and SHG44) were evaluated, and compound 7 displayed certain inhibitory effect with IC50 values of 15.22 ± 1.73, 18.87 ± 1.81 and 17.64 ± 1.69 μmol·L-1, respectively.
