Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism.
10.1016/S1875-5364(23)60496-0
- Author:
Junchi ZHOU
1
,
2
;
Qilin FAN
1
,
2
;
Xiaoying CAI
1
,
2
;
Youying ZHANG
1
,
2
;
Yuanlong HOU
1
,
2
;
Shuqi CAO
1
,
2
;
Ziguang LI
1
,
2
;
Mengzhen FENG
1
,
2
;
Qingqing WANG
3
;
Jianbing ZHANG
3
;
Guangji WANG
1
,
2
;
Xiao ZHENG
1
,
4
;
Haiping HAO
1
,
5
Author Information
1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
2. Laboratory of Metabolic Regulation and Drug Target Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
3. WanBangDe Pharmaceutical Group Co., Ltd., Wenlin 317500, China.
4. Laboratory of Metabolic Regulation and Drug Target Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: xzheng@cpu.edu.cn.
5. Laboratory of Metabolic Regulation and Drug Target Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: haipinghao@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Bile acid;
Depression;
Ginkgo biloba extract;
Gut microbiome;
Gut-brain axis
- MeSH:
Humans;
Mice;
Animals;
Depression/drug therapy*;
Gastrointestinal Microbiome;
Plant Extracts;
Ginkgo biloba
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(10):745-758
- CountryChina
- Language:English
-
Abstract:
Depression is a mental disorder with high morbidity, disability and relapse rates. Ginkgo biloba extract (GBE), a traditional Chinese medicine, has a long history of clinical application in the treatment of cerebral and mental disorders, but the key mechanism remains incompletely understood. Here we showed that GEB exerted anti-depressant effect in mice through regulating gut microbial metabolism. GBE protected against unpredictable mild stress (UMS)-induced despair, anxiety-like and social avoidance behavior in mice without sufficient brain distribution. Fecal microbiome transplantation transmitted, while antibiotic cocktail abrogated the protective effect of GBE. Spatiotemporal bacterial profiling and metabolomics assay revealed a potential involvement of Parasutterella excrementihominis and the bile acid metabolite ursodeoxycholic acid (UDCA) in the effect of GBE. UDCA administration induced depression-like behavior in mice. Together, these findings suggest that GBE acts on gut microbiome-modulated bile acid metabolism to alleviate stress-induced depression.
