Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8.

Ying HU; Shuxian Wang; Lan WU; Kai Yang; Fan Yang; Junfa Yang; Shuang HU; Yan Yao; Xun Xia; Yixin Liu; Li Peng; Jihong Wan; Chuanpu Shen; Tao XU

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Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8.

Author: Ying HU ^{1
,

2
,

3} ; Shuxian WANG ^{1
,

2
,

3} ; Lan WU ^{1
,

2
,

3} ; Kai YANG ^{1
,

2
,

4
,

5} ; Fan YANG ⁶ ; Junfa YANG ^{1
,

2
,

3} ; Shuang HU ^{1
,

2
,

3} ; Yan YAO ^{1
,

2
,

3} ; Xun XIA ^{1
,

2
,

3} ; Yixin LIU ^{1
,

2
,

3} ; Li PENG ^{1
,

2
,

3} ; Jihong WAN ^{1
,

2
,

3} ; Chuanpu SHEN ^{1
,

2
,

7} ; Tao XU ^{1
,

2
,

8}
Author Information

1. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province
2. School of Pharmacy, Anhui Medical University, Hefei 230032, China
3. Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China.
4. Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China
5. Medical Device Production Supervision Office, Anhui Provincial Drug Administration, Hefei 230051, China.
6. Department of Ophthalmology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
7. Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China. Electronic address: shenchuanpu@126.com.
8. Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China. Electronic address: xutao@ahmu.edu.cn.
Publication Type:Journal Article
Keywords: Alcoholic liver disease; Inflammatory; Lipid accumulation; MMP8; Puerarin
From: Chinese Journal of Natural Medicines (English Ed.) 2023;21(9):670-681
CountryChina
Language:English
Abstract: Alcoholic liver disease (ALD) is a growing global health concern, and its early pathogenesis includes steatosis and steatohepatitis. Inhibiting lipid accumulation and inflammation is a crucial step in relieving ALD. Evidence shows that puerarin (Pue), an isoflavone isolated from Pueraria lobata, exerts cardio-protective, neuroprotective, anti-inflammatory, antioxidant activities. However, the therapeutic potential of Pue on ALD remains unknown. In the study, both the NIAAA model and ethanol (EtOH)-induced AML-12 cell were used to explore the protective effect of Pue on alcoholic liver injury in vivo and in vitro and related mechanism. The results showed that Pue (100 mg·kg^-1) attenuated EtOH-induced liver injury and inhibited the levels of SREBP-1c, TNF-α, IL-6 and IL-1β, compared with silymarin (Sil, 100 mg·kg^-1). In vitro results were consistent within vivo results. Mechanistically, Pue might suppress liver lipid accumulation and inflammation by regulating MMP8. In conclusion, Pue might be a promising clinical candidate for ALD treatment.