Research progress on the pharmacological effects and chemical constituents of Pien Tze Huang and its potential Q-markers.
10.1016/S1875-5364(23)60400-5
- Author:
Zhaomin DONG
1
;
Hong WANG
1
;
Guangji WANG
2
Author Information
1. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Research Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical Sciences, China Pharmaceutical University, Nanjing 210009, China.
2. Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Research Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical Sciences, China Pharmaceutical University, Nanjing 210009, China. Electronic address: gjwang@cpu.edu.cn.
- Publication Type:Review
- Keywords:
Chemical components;
Clinical application;
Pharmacological effects;
Pien Tze Huang (PTH);
Quality control;
Quality marker (Q-marker)
- MeSH:
Humans;
Ginsenosides/pharmacology*;
Drugs, Chinese Herbal/pharmacology*;
Medicine, Chinese Traditional;
Neoplasms;
Quality Control;
China
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(9):658-669
- CountryChina
- Language:English
-
Abstract:
Pien Tze Huang (PTH) was documented as an imperial prescription composed of Notoginseng Radix, Calculus Bovis, Snake Gallbladder, and Musk. It is famous in China and Asian countries due to its excellent effects in heat clearing, detoxifying, swelling reduction, and pain relieving. Modern pharmacological studies demonstrate that PTH shows excellent effects against various inflammatory diseases, liver diseases, and cancers. This review summaries the pharmacological effects, clinical applications, and mainchemical components of PTH. More importantly, its potential quality markers (Q-markers) were then analyzed based on the "five principles" of Q-markers under the guidance of Traditional Chinese Medicine theory, including transfer and traceability, specificity, efficacy, compatibility, and measurability. As a result, ginsenosides Rb1, ginsenoside Rg1, ginsenoside Rd, ginsenoside Re, notoginsenoside R1, dencichine, bilirubin, biliverdin, taurocholic acid, and muscone are considered as the Q-markers of PTH. These findings will provide guidance and assistance for the construction of a quality control system for PTH.
