Antimalarial and neuroprotective ent-abietane diterpenoids from the aerial parts of Phlogacanthus curviflorus.
10.1016/S1875-5364(23)60464-9
- Author:
Jia LI
1
;
Xiao MENG
1
;
Chengyue YIN
1
;
Lixia ZHANG
1
;
Bin LIN
2
;
Peng LIU
3
;
Lingjuan ZHU
1
;
Haifeng WANG
1
;
Hongwei LIU
4
;
Xue ZHANG
5
;
Xinsheng YAO
6
,
7
Author Information
1. School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
3. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
4. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
5. School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: syzxalice@163.com.
6. School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
7. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: tyaoxs@jnu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Acathaceae;
Antimalarial activity;
Neuroprotective effect;
Phlogacanthus curviflorus;
ent-Abietane diterpenoids
- MeSH:
Abietanes/pharmacology*;
Antimalarials;
Hydrogen Peroxide;
Biological Assay;
Plant Components, Aerial
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(8):619-630
- CountryChina
- Language:English
-
Abstract:
Six new ent-abietane diterpenoids, abientaphlogatones A-F (1-6), along with two undescribed ent-abietane diterpenoid glucosides, abientaphlogasides A-B (7-8) and four known analogs were isolated from the aerial parts ofPhlogacanthus curviflorus (P. curviflorus). The structures of these compounds were determined using high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), one-dimensional and two-dimensional nuclear magnetic resonance (NMR) spectroscopy, electronic circular dichroism (ECD) spectra, and quantum chemical calculations. Notably, compounds 5 and 6 represented the first reported instances of ent-norabietane diterpenoids from the genus Phlogacanthus. In the β-hematin formation inhibition assay, compounds 2, 4, 7-10, and 12 displayed antimalarial activity, with IC50 values of 12.97-65.01 μmol·L-1. Furthermore, compounds 4, 5, 8, and 10 demonstrated neuroprotective activity in PC12 cell injury models induced by H2O2 and MPP+.
