Prognostic significance of T2 mapping in evaluating myocardium alterations in patients with ST segment elevation myocardial infarction.
10.3760/cma.j.cn121430-20230914-00779
- Author:
Qian CUI
1
;
Qiang HE
2
;
Xihong GE
3
;
Guangfeng GAO
3
;
Yang LIU
3
;
Jing YU
3
;
Hongle WANG
3
;
Wen SHEN
1
Author Information
1. The First Central Clinical School, Tianjin Medical University, Tianjin 300192, China.
2. Department of Cardiology, Tianjin First Central Hospital, Tianjin 300192, China. Corresponding author: Shen Wen, Email: shenwen66happy@126.com.
3. Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, China.
- Publication Type:Journal Article
- MeSH:
Humans;
ST Elevation Myocardial Infarction/diagnosis*;
Contrast Media;
Prognosis;
Retrospective Studies;
Magnetic Resonance Imaging, Cine/methods*;
Gadolinium;
Myocardium/pathology*;
Myocardial Infarction;
Predictive Value of Tests
- From:
Chinese Critical Care Medicine
2023;35(12):1304-1308
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the value of T2 mapping in the assessment of myocardial changes and prognosis in patients with acute ST segment elevation myocardial infarction (STEMI).
METHODS:A retrospective study was conducted. A total of 30 patients with acute STEMI admitted to Tianjin First Central Hospital from January 2021 to March 2022 were enrolled as the experimental group. At the same time, 30 age- and sex-matched healthy volunteers and outpatients with non-specific chest pain with no abnormalities in cardiac magnetic resonance (CMR) examination were selected as the control group. CMR was performed within 2 weeks after the diagnosis of STEMI, as the initial reference. A plain CMR review was performed 6 months later (chronic myocardial infarction, CMI). Plain scanning includes film sequence (CINE), T2 weighted short tau inversion recovery (T2-STIR), native-T1 mapping, and T2 mapping. Enhanced scanning includes first-pass perfusion, late gadolinium enhancement (LGE), and post-contrast T1 mapping. Quantitative myocardial parameters were compared between the two groups, before and after STEMI myocardial infarction. The receiver operator characteristic curve (ROC curve) was used to evaluate the diagnostic efficacy of native-T1 before myocardial contrast enhancement and T2 values in differentiating STEMI and CMI after 6 months.
RESULTS:There were no statistically significant differences in age, gender, heart rate and body mass index (BMI) between the two groups, which were comparable. The native-T1 value, T2 value and extracellular volume (ECV) were significantly higher than those in the control group [native-T1 value (ms): 1 434.5±165.3 vs. 1 237.0±102.5, T2 value (ms): 48.3±15.6 vs. 21.8±13.1, ECV: (39.6±13.8)% vs. (22.8±5.0)%, all P < 0.05]. In the experimental group, 12 patients were re-examined by plain CMR scan 6 months later. After 6 months, the high signal intensity on T2-STIR was still visible, but the range was smaller than that in the acute phase, and the native-T1 and T2 values were significantly lower than those in the acute phase [native-T1 value (ms): 1 271.0±26.9 vs. 1 434.5±165.3, T2 value (ms): 34.2±11.2 vs. 48.3±15.6, both P < 0.05]. ROC curve analysis showed that the area under the ROC curve (AUC) of native-T1 and T2 values in differentiating acute STEMI from CMI was 0.71 and 0.80, respectively. When native-T1 cut-off value was 1 316.0 ms, the specificity was 100% and the sensitivity was 53.3%; when T2 cut-off value was 46.7 ms, the specificity was 100% and the sensitivity was 73.8%.
CONCLUSIONS:The T2 mapping is a non-invasive method for the diagnosis of myocardial changes in patients with acute STEMI myocardial infarction, and can be used to to evaluate the clinical prognosis of patients.
