Research progress of metabolomics in acute kidney injury.
10.3760/cma.j.cn121430-20230418-00294
- Author:
Heng ZHAO
1
;
Fang FENG
;
Chenming DONG
Author Information
1. Department of Critical Care Medicine, the Second Hospital of Lanzhou University, Lanzhou 730030, Gansu, China. Corresponding author: Dong Chenming, Email: ery_dongchm@lzu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
Acute Kidney Injury/metabolism*;
Metabolomics;
Prognosis;
Biomarkers;
Precision Medicine
- From:
Chinese Critical Care Medicine
2023;35(10):1111-1115
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury (AKI) is caused by a variety of diseases, which leads to acute renal function decline, azotemia, water and electrolyte disorders and acid-base balance disorders. Metabolomics is a research method that can quantitatively analyze all metabolites in an organism and find the relative relationship between metabolites and physiological and pathological changes. In recent years, several metabolites screened based on metabolomics have been proposed as potential biomarkers to assess the early development and prognosis of AKI and for the discovery of unknown potential therapeutic targets. Based on metabolomics, this paper reviews the risk prediction, early diagnosis, disease monitoring, prognosis assessment and the application of corresponding drugs for AKI, so as to provide reference for precision medicine.
