Research progress of Mendelian randomization analysis in intensive care medicine.
10.3760/cma.j.cn121430-20230405-00244
- Author:
Shengyu HUANG
1
;
Jiaqi LI
1
;
Feng ZHU
2
Author Information
1. Medical Center of Burn Plastic and Wound Repair, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
2. Department of Burn, the First Affiliated Hospital, Naval Medical University, Shanghai 200433, China. Corresponding author: Zhu Feng, Email: alexzhufeng0816@vip.sina.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Mendelian Randomization Analysis/methods*;
Genetic Variation;
Causality;
Research Design
- From:
Chinese Critical Care Medicine
2023;35(10):1101-1105
- CountryChina
- Language:Chinese
-
Abstract:
The condition of critically ill patients changes rapidly, involving pathological changes in multiple systems and organs throughout the body. Exploring the causal relationship of mechanisms can further reveal etiology, treatment, and prognosis of diseases. However, traditional prospective studies in the field of critical care are still subject to numerous limitations. As an emerging research method, Mendelian randomization (MR) analysis uses genetic variation to provide causal evidence for instrumental variables, which is expected to provide clues in critical diseases. This article systematically describes the research progresson the application of MR analysis in critical care medicine from four aspects: the principle of MR analysis, the difference between MR analysis and randomized controlled trial (RCT), the use of MR analysis in the field of critical illness, and the possible methods of application, aiming to provide possible directions for the research in this field.
