Research progress of exosomes in the diagnosis and treatment of sepsis.
10.3760/cma.j.cn121430-20221031-00957
- Author:
Xin DU
1
;
Hui FENG
;
Yuhao JIANG
;
Zihao FAN
;
Hengheng ZHENG
;
Jianjun ZHU
Author Information
1. Department of Emergency, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China. Corresponding author: Zhu Jianjun, Email: 13616203651@163.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Shock, Septic/therapy*;
Exosomes/metabolism*;
Sepsis/therapy*;
Extracellular Vesicles/metabolism*;
RNA/metabolism*
- From:
Chinese Critical Care Medicine
2023;35(9):999-1003
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by infection that lead to dysregulation of the host response. Sepsis and septic shock with a high mortality threaten human health at present, which are important medical and health problems. Early diagnosis and treatment decision-making for sepsis and septic shock still need to be improved. Exosomes are extracellular vesicles with a diameter of 30-150 nm formed by the fusion of multi-vesicle bodies and cell membranes. Exosomes can effectively transport a variety of bioactive substances such as proteins, lipids, RNA, DNA, and participate in the regulation of inflammatory response, immune response, infection and other pathophysiological processes. In recent years, exosomes have become one of the important methods for the diagnosis and treatment of systemic inflammatory diseases. This article will focus on the basic and clinical research of sepsis, and focus on the research progress of exosomes in the diagnosis and targeted therapy of sepsis.
