Research progress on the role of histone modification in sepsis.
10.3760/cma.j.cn121430-20230404-00243
- Author:
Fan GE
1
;
Jun LU
Author Information
1. Department of Intensive Care Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, Jiangsu, China. Corresponding author: Lu Jun, Email: lujun@njucm.edu.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
Histone Code;
Sepsis/metabolism*;
Critical Illness;
Macrophage Activation
- From:
Chinese Critical Care Medicine
2023;35(9):995-998
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by dysregulated body response to infection. It is also one of the major causes of death in critically ill patients. Over the past few years, despite the continuous improvement in the treatment of sepsis, there is no specific treatment, clinical morbidity and mortality are still rising. Therefore, finding effective methods to treat sepsis and reduce mortality is an urgent clinical problem. Histone modification is an epigenetic modification that produces heritable phenotypic changes without altering the DNA sequence. In recent years, many studies have shown that histone modification is closely related to sepsis. This review discusses the mechanism of histone modification in the pathogenesis of sepsis from the aspects of inflammatory factors, signaling pathways, and macrophage polarization, in aimed to provide reference for the clinical treatment of sepsis.
