Phase separation in cGAS-STING signaling.
10.1007/s11684-023-1026-6
- Author:
Quanjin LI
1
;
Pu GAO
2
Author Information
1. CAS Key Laboratory of Infection and Immunity, National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. liquanjin@ibp.ac.cn.
2. CAS Key Laboratory of Infection and Immunity, National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. gaopu@ibp.ac.cn.
- Publication Type:Review
- Keywords:
STING;
biomolecular condensates;
cGAMP;
cGAS;
cGAS-STING pathway;
interferon;
phase separation
- MeSH:
Humans;
Nucleotidyltransferases/chemistry*;
Signal Transduction/physiology*;
Membrane Proteins/chemistry*;
Phase Separation
- From:
Frontiers of Medicine
2023;17(5):855-866
- CountryChina
- Language:English
-
Abstract:
Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STING signaling functions to detect aberrant DNA signals to initiate anti-infection defense and antitumor immunity. At the same time, cGAS-STING signaling must be carefully regulated to maintain immune homeostasis. Interestingly, exciting recent studies have reported that biomolecular phase separation exists and plays important roles in different steps of cGAS-STING signaling, including cGAS condensates, STING condensates, and IRF3 condensates. In addition, several intracellular and extracellular factors have been proposed to modulate the condensates in cGAS-STING signaling. These studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide new opportunities for drug discovery. Here, we summarize recent advances in the phase separation of cGAS-STING signaling and the development of potential drugs targeting these innate immune condensates.
