Fallopian Metaplastic Papillary Tumour: An Atypical Transdifferentiation of the Tubal Epithelium?.
- Author:
Miguel Fdo SALAZAR
1
;
Isaias Estrada MOSCOSO
;
Lorena Troncoso VAZQUEZ
;
Nubia Leticia LOPEZ GARCIA
;
Paola Andrea ESCALANTE ABRIL
Author Information
- Publication Type:Case Report
- Keywords: Metaplastic papillary tumour; Fallopian tubes; Arias-Stella reaction; Cell transdifferentiation
- MeSH: Adult; Cell Transdifferentiation; Cyclin D1; Eosinophils; Epithelium*; Fallopian Tubes; Female; Humans; Immunohistochemistry; Microscopy; Mucin-1; Parturition; Pregnancy; Sterilization, Tubal
- From:Journal of Pathology and Translational Medicine 2015;49(2):148-155
- CountryRepublic of Korea
- Language:English
- Abstract: A metaplastic papillary tumor of the Fallopian tube is an extremely uncommon condition, with odd and confusing features that make it difficult to categorize as benign or borderline. Here, we summarize all the published cases to date and document the case of a 41-year-old woman diagnosed with this alteration after her last childbirth and ensuing tubal ligation. One of the tubes was bulky and filled with a caramel-like substance encircling a blurry spot. Light microscopy detailed a slender stalk covered by eosinophilic, columnar plump cells, showing atypical nuclei and focal budding. Mitotic figures were absent. The immunohistochemistry panel was positive for pan-cytokeratin, epithelial membrane antigen, cyclin D1, and hormone receptors. Additionally, a proliferation index of less than 5% was rated using Ki-67. The true nature of this tumor (reactive vs neoplastic) is uncertain. Nonetheless, its association with pregnancy suggests an adaptive change, likely similar to the atypical transdifferentiation proposed for Arias-Stella reaction.
