Cellular polyploidy in organ homeostasis and regeneration.

Juntao Fang; Alain DE Bruin; Andreas Villunger; Raymond Schiffelers; Zhiyong Lei; Joost P G Sluijter

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Cellular polyploidy in organ homeostasis and regeneration.

Author: Juntao FANG ¹ ; Alain DE BRUIN ² ; Andreas VILLUNGER ³ ; Raymond SCHIFFELERS ⁴ ; Zhiyong LEI ¹ ; Joost P G SLUIJTER ¹
Author Information

1. Department of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
2. Department of Pediatrics, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
3. Institute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria.
4. CDL Research, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Publication Type:Research Support, Non-U.S. Gov't
Keywords: cardiac regeneration; cellular polyploidy; liver regeneration; tissue regeneration
MeSH: Humans; Liver; Hepatocytes; Cell Cycle; Polyploidy; Homeostasis
From: Protein & Cell 2023;14(8):560-578
CountryChina
Language:English
Abstract: Polyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals. Here, we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid. Moreover, we discuss its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.