An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral.

Author: Miao MEI ¹ ; Maria Antonietta IMPAGNATIELLO ² ; Jun JIAO ¹ ; Ulrich REISER ² ; Ulrike TONTSCH-GRUNT ² ; Ju ZHANG ³ ; Paul NICKLIN ⁴ ; Bingke YU ⁵ ; Yu WANG ³ ; Yuan HE ⁵ ; Xu TAN ¹
Author Information

1. Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
2. Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
3. College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
4. Research Beyond Borders, Boehringer Ingelheim, Biberach an der Riss, Germany.
5. Research Beyond Borders, Boehringer Ingelheim, Shanghai 200120, China.
Publication Type:Journal Article
MeSH: Apoptosis Regulatory Proteins; Apoptosis; Antiviral Agents/pharmacology*; Mitochondrial Proteins; Cell Line, Tumor; Antineoplastic Agents/pharmacology*
From: Protein & Cell 2024;15(1):69-75
CountryChina
Language:English