Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke.
10.1016/j.chmed.2023.09.003
- Author:
Hanyu ZHANG
1
;
Bowen JIN
1
;
Xinyu YOU
1
;
Pengrong YI
1
;
Hong GUO
1
;
Lin NIU
1
;
Qingsheng YIN
1
;
Jiangwei SHI
2
;
Yanjun ZHANG
2
;
Pengwei ZHUANG
1
Author Information
1. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
2. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
- Publication Type:Review
- Keywords:
ischemic stroke;
secondary prevention;
syndrome differentiation and treatment;
traditional Chinese medicine;
traditional Chinese medicine dominant disease
- From:
Chinese Herbal Medicines
2023;15(4):496-508
- CountryChina
- Language:English
-
Abstract:
Ischemic stroke (IS) is a severe cerebrovascular disease with a high incidence, mortality, and disability rate. The first-line treatment for IS is the use of recombinant tissue plasminogen activator (r-tPA). Regrettably, numerous patients encounter delays in treatment due to the narrow therapeutic window and the associated risk of hemorrhage. Traditional Chinese medicine (TCM) has exhibited distinct advantages in preventing and treating IS. TCM enhances cerebral microcirculation, alleviates neurological disorders, regulates energy metabolism, mitigates inflammation, reduces oxidative stress injuries, and inhibits apoptosis, thereby mitigating brain damage and preventing IS recurrence. This article summarizes the etiology, pathogenesis, therapeutic strategies, and relationship with modern biology of IS from the perspective of TCM, describes the advantages of TCM in the treatment of IS, and further reviews the pharmacodynamic characteristics and advantages of TCM in the acute and recovery phases of IS as well as in post-stroke complications. Additionally, it offers valuable insights and references for the clinical application of TCM in IS prevention and treatment, as well as for the development of novel drugs.
