Molecular mechanisms of cellular metabolic homeostasis in stem cells.
10.1038/s41368-023-00262-z
- Author:
Xiaoyu LI
1
;
Ou JIANG
1
;
Songlin WANG
2
Author Information
1. Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
2. Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, China. slwang@ccmu.edu.cn.
- Publication Type:Review
- MeSH:
Stem Cells/metabolism*;
Homeostasis/physiology*;
Cell Differentiation/physiology*
- From:
International Journal of Oral Science
2023;15(1):52-52
- CountryChina
- Language:English
-
Abstract:
Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis plays a central role in mediating stem cell fate, tissue regeneration, and homeostasis. Thus, a thorough understanding of the mechanisms that regulate metabolic homeostasis in stem cells may contribute to our knowledge on how tissue homeostasis is maintained and provide novel insights for disease management. In this review, we summarize the known relationship between the regulation of metabolic homeostasis and molecular pathways in stem cells. We also discuss potential targets of metabolic homeostasis in disease therapy and describe the current limitations and future directions in the development of these novel therapeutic targets.
