Theta Oscillations Support Prefrontal-hippocampal Interactions in Sequential Working Memory.
10.1007/s12264-023-01134-6
- Author:
Minghong SU
1
;
Kejia HU
2
;
Wei LIU
2
;
Yunhao WU
2
;
Tao WANG
2
;
Chunyan CAO
2
;
Bomin SUN
2
;
Shikun ZHAN
3
;
Zheng YE
4
Author Information
1. Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.
2. Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
3. Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. zsk10715@rjh.com.cn.
4. Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China. yez@ion.ac.cn.
- Publication Type:Journal Article
- Keywords:
Dorsolateral prefrontal cortex;
Granger causality;
Hippocampus;
Phase coherence;
Sequential working memory;
Stereoelectroencephalography (SEEG);
Theta oscillations
- MeSH:
Adult;
Female;
Humans;
Young Adult;
Epilepsy;
Hippocampus;
Memory, Short-Term;
Mental Recall;
Prefrontal Cortex;
Theta Rhythm;
Male
- From:
Neuroscience Bulletin
2024;40(2):147-156
- CountryChina
- Language:English
-
Abstract:
The prefrontal cortex and hippocampus may support sequential working memory beyond episodic memory and spatial navigation. This stereoelectroencephalography (SEEG) study investigated how the dorsolateral prefrontal cortex (DLPFC) interacts with the hippocampus in the online processing of sequential information. Twenty patients with epilepsy (eight women, age 27.6 ± 8.2 years) completed a line ordering task with SEEG recordings over the DLPFC and the hippocampus. Participants showed longer thinking times and more recall errors when asked to arrange random lines clockwise (random trials) than to maintain ordered lines (ordered trials) before recalling the orientation of a particular line. First, the ordering-related increase in thinking time and recall error was associated with a transient theta power increase in the hippocampus and a sustained theta power increase in the DLPFC (3-10 Hz). In particular, the hippocampal theta power increase correlated with the memory precision of line orientation. Second, theta phase coherences between the DLPFC and hippocampus were enhanced for ordering, especially for more precisely memorized lines. Third, the theta band DLPFC → hippocampus influence was selectively enhanced for ordering, especially for more precisely memorized lines. This study suggests that theta oscillations may support DLPFC-hippocampal interactions in the online processing of sequential information.
