Alterations of Audiovisual Integration in Alzheimer's Disease.
10.1007/s12264-023-01125-7
- Author:
Yufei LIU
1
;
Zhibin WANG
1
;
Tao WEI
1
;
Shaojiong ZHOU
1
;
Yunsi YIN
1
;
Yingxin MI
1
;
Xiaoduo LIU
1
;
Yi TANG
2
Author Information
1. Department of Neurology and Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, 100053, China.
2. Department of Neurology and Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, 100053, China. tangyi@xwhosp.org.
- Publication Type:Review
- Keywords:
Aging;
Alzheimer’s disease;
Audiovisual integration;
Cognition;
Sensory information process
- MeSH:
Animals;
Humans;
Alzheimer Disease/pathology*;
Brain/pathology*;
Aging/physiology*;
Cognition
- From:
Neuroscience Bulletin
2023;39(12):1859-1872
- CountryChina
- Language:English
-
Abstract:
Audiovisual integration is a vital information process involved in cognition and is closely correlated with aging and Alzheimer's disease (AD). In this review, we evaluated the altered audiovisual integrative behavioral symptoms in AD. We further analyzed the relationships between AD pathologies and audiovisual integration alterations bidirectionally and suggested the possible mechanisms of audiovisual integration alterations underlying AD, including the imbalance between energy demand and supply, activity-dependent degeneration, disrupted brain networks, and cognitive resource overloading. Then, based on the clinical characteristics including electrophysiological and imaging data related to audiovisual integration, we emphasized the value of audiovisual integration alterations as potential biomarkers for the early diagnosis and progression of AD. We also highlighted that treatments targeted audiovisual integration contributed to widespread pathological improvements in AD animal models and cognitive improvements in AD patients. Moreover, investigation into audiovisual integration alterations in AD also provided new insights and comprehension about sensory information processes.
