Genetic Architecture and Functional Implications of the CSF-Contacting Nucleus.
10.1007/s12264-023-01084-z
- Author:
Siyuan SONG
1
;
Yumin YUAN
1
;
Lingling XU
1
;
Jun JIANG
1
;
Ying LI
1
;
Yao YAN
1
;
Qing LI
1
;
Fang ZHOU
1
;
Junli CAO
1
;
Licai ZHANG
2
Author Information
1. Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.
2. Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China. licaizhang001@163.com.
- Publication Type:Journal Article
- Keywords:
Biological function;
Cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus);
Gene architecture
- MeSH:
Rats;
Animals;
Rats, Sprague-Dawley;
Serotonin/metabolism*;
Signal Transduction;
Cerebrospinal Fluid/metabolism*
- From:
Neuroscience Bulletin
2023;39(11):1638-1654
- CountryChina
- Language:English
-
Abstract:
We previously identified a unique nucleus, the cerebrospinal fluid (CSF)-contacting nucleus. This study aims to understand its gene architecture and preliminarily suggest its functions. The results showed that there were about 19,666 genes in this nucleus, of which 913 were distinct from the dorsal raphe nucleus (non-CSF contacting). The top 40 highly-expressed genes are mainly related to energy metabolism, protein synthesis, transport, secretion, and hydrolysis. The main neurotransmitter is 5-HT. The receptors of 5-HT and GABA are abundant. The channels for Cl-, Na+, K+, and Ca2+ are routinely expressed. The signaling molecules associated with the CaMK, JAK, and MAPK pathways were identified accurately. In particular, the channels of transient receptor potential associated with nociceptors and the solute carrier superfamily members associated with cell membrane transport were significantly expressed. The relationship between the main genes of the nucleus and life activities is preliminarily verified.
