The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior.
10.1007/s12264-023-01073-2
- Author:
Jing LIU
1
;
Dechen LIU
1
;
Xiaotian PU
1
;
Kexin ZOU
1
;
Taorong XIE
1
;
Yaping LI
1
;
Haishan YAO
2
Author Information
1. Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
2. Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China. haishanyao@ion.ac.cn.
- Publication Type:Journal Article
- Keywords:
Choice signal;
Direct and indirect pathway striatal neurons;
Secondary motor cortex;
Striatum;
Visual perceptual decision
- MeSH:
Mice;
Animals;
Motor Cortex;
Corpus Striatum/physiology*;
Neostriatum;
Neurons/physiology*;
Reaction Time
- From:
Neuroscience Bulletin
2023;39(10):1544-1560
- CountryChina
- Language:English
-
Abstract:
The secondary motor cortex (M2) encodes choice-related information and plays an important role in cue-guided actions. M2 neurons innervate the dorsal striatum (DS), which also contributes to decision-making behavior, yet how M2 modulates signals in the DS to influence perceptual decision-making is unclear. Using mice performing a visual Go/No-Go task, we showed that inactivating M2 projections to the DS impaired performance by increasing the false alarm (FA) rate to the reward-irrelevant No-Go stimulus. The choice signal of M2 neurons correlated with behavioral performance, and the inactivation of M2 neurons projecting to the DS reduced the choice signal in the DS. By measuring and manipulating the responses of direct or indirect pathway striatal neurons defined by M2 inputs, we found that the indirect pathway neurons exhibited a shorter response latency to the No-Go stimulus, and inactivating their early responses increased the FA rate. These results demonstrate that the M2-to-DS pathway is crucial for suppressing inappropriate responses in perceptual decision behavior.
