Reproducible Abnormalities and Diagnostic Generalizability of White Matter in Alzheimer's Disease.

Yida QU; Pan Wang; Hongxiang Yao; Dawei Wang; Chengyuan Song; Hongwei Yang; Zengqiang Zhang; Pindong Chen; Xiaopeng Kang; Kai DU; Lingzhong Fan; Bo Zhou; Tong Han; Chunshui YU; Xi Zhang; Nianming Zuo; Tianzi Jiang; Yuying Zhou; Bing Liu; Ying Han; Jie LU; Yong Liu

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Reproducible Abnormalities and Diagnostic Generalizability of White Matter in Alzheimer's Disease.

Author: Yida QU ¹ ; Pan WANG ² ; Hongxiang YAO ² ; Dawei WANG ³ ; Chengyuan SONG ⁴ ; Hongwei YANG ⁵ ; Zengqiang ZHANG ⁶ ; Pindong CHEN ¹ ; Xiaopeng KANG ¹ ; Kai DU ¹ ; Lingzhong FAN ¹ ; Bo ZHOU ⁷ ; Tong HAN ⁸ ; Chunshui YU ⁹ ; Xi ZHANG ⁷ ; Nianming ZUO ¹ ; Tianzi JIANG ¹ ; Yuying ZHOU ² ; Bing LIU ¹ ; Ying HAN ¹⁰ ; Jie LU ¹¹ ; Yong LIU ¹²
Author Information

1. Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
2. Department of Neurology, Tianjin Huanhu Hospital, Tianjin University, Tianjin, 300222, China.
3. Department of Radiology, Department of Epidemiology and Health Statistics, School of Public Health, Qilu Hospital of Shandong University, Ji'nan, 250063, China.
4. Department of Neurology, Qilu Hospital of Shandong University, Ji'nan, 250063, China.
5. Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
6. Branch of Chinese, PLA General Hospital, Sanya, 572022, China.
7. Department of Neurology, The Second Medical Centre, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100089, China.
8. Department of Radiology, Tianjin Huanhu Hospital, Tianjin, 300222, China.
9. Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
10. Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
11. Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China. imaginglu@hotmail.com.
12. Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. yongliu@bupt.edu.cn.
Collective Name:Multi-Center Alzheimer’s Disease Imaging (MCADI) Consortium
Publication Type:Journal Article
Keywords: Alzheimer’s disease; Cross-validation; Diffusion tensor imaging; White matter tracts
MeSH: Humans; White Matter/diagnostic imaging*; Diffusion Tensor Imaging/methods*; Alzheimer Disease/complications*; Reproducibility of Results; Cognition; Cognitive Dysfunction/complications*; Brain/diagnostic imaging*
From: Neuroscience Bulletin 2023;39(10):1533-1543
CountryChina
Language:English
Abstract: Alzheimer's disease (AD) is associated with the impairment of white matter (WM) tracts. The current study aimed to verify the utility of WM as the neuroimaging marker of AD with multisite diffusion tensor imaging datasets [321 patients with AD, 265 patients with mild cognitive impairment (MCI), 279 normal controls (NC)], a unified pipeline, and independent site cross-validation. Automated fiber quantification was used to extract diffusion profiles along tracts. Random-effects meta-analyses showed a reproducible degeneration pattern in which fractional anisotropy significantly decreased in the AD and MCI groups compared with NC. Machine learning models using tract-based features showed good generalizability among independent site cross-validation. The diffusion metrics of the altered regions and the AD probability predicted by the models were highly correlated with cognitive ability in the AD and MCI groups. We highlighted the reproducibility and generalizability of the degeneration pattern of WM tracts in AD.