Circuit-Specific Control of Blood Pressure by PNMT-Expressing Nucleus Tractus Solitarii Neurons.
10.1007/s12264-022-01008-3
- Author:
Shirui JUN
1
;
Xianhong OU
2
;
Luo SHI
1
;
Hongxiao YU
1
;
Tianjiao DENG
1
;
Jinting CHEN
3
;
Xiaojun NIE
1
;
Yinchao HAO
1
;
Yishuo SHI
1
;
Wei LIU
1
;
Yanming TIAN
1
;
Sheng WANG
4
;
Fang YUAN
5
Author Information
1. Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
2. Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, China.
3. Core Facilities and Centers, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, China.
4. Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China. wangsheng@hebmu.edu.cn.
5. Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China. yuanfphy@163.com.
- Publication Type:Journal Article
- Keywords:
Blood pressure;
Neural circuit;
Nucleus tractus solitarii;
Optogenetics;
Rostral ventrolateral medulla
- MeSH:
Solitary Nucleus/metabolism*;
Blood Pressure/physiology*;
Phenylethanolamine N-Methyltransferase/metabolism*;
Neurons/metabolism*;
Paraventricular Hypothalamic Nucleus/metabolism*
- From:
Neuroscience Bulletin
2023;39(8):1193-1209
- CountryChina
- Language:English
-
Abstract:
The nucleus tractus solitarii (NTS) is one of the morphologically and functionally defined centers that engage in the autonomic regulation of cardiovascular activity. Phenotypically-characterized NTS neurons have been implicated in the differential regulation of blood pressure (BP). Here, we investigated whether phenylethanolamine N-methyltransferase (PNMT)-expressing NTS (NTSPNMT) neurons contribute to the control of BP. We demonstrate that photostimulation of NTSPNMT neurons has variable effects on BP. A depressor response was produced during optogenetic stimulation of NTSPNMT neurons projecting to the paraventricular nucleus of the hypothalamus, lateral parabrachial nucleus, and caudal ventrolateral medulla. Conversely, photostimulation of NTSPNMT neurons projecting to the rostral ventrolateral medulla produced a robust pressor response and bradycardia. In addition, genetic ablation of both NTSPNMT neurons and those projecting to the rostral ventrolateral medulla impaired the arterial baroreflex. Overall, we revealed the neuronal phenotype- and circuit-specific mechanisms underlying the contribution of NTSPNMT neurons to the regulation of BP.
