Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases.

Yi Luan; Yang Yang; Ying Luan; Hui Liu; Han Xing; Jinyan Pei; Hengdao Liu; Bo Qin; Kaidi Ren

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Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases.

Author: Yi LUAN ¹ ; Yang YANG ¹ ; Ying LUAN ² ; Hui LIU ³ ; Han XING ⁴ ; Jinyan PEI ⁵ ; Hengdao LIU ⁶ ; Bo QIN ⁷ ; Kaidi REN ⁸
Author Information

1. Clinical Systems Biology Research Laboratories, Translational Medicine Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
2. State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China.
3. School of Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China.
4. Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
5. Quality Management Department, Henan No. 3 Provincial People's Hospital, Zhengzhou 450052, China.
6. Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. renkd006@163.com, fccliuhd@zzu.edu.cn.
7. Center for Translational Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. renkd006@163.com, boqin@mail.ustc.edu.cn.
8. Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. renkd006@163.com.
Publication Type:Journal Article
Keywords: Cardiovascular disease; Ferritinophagy; Ferroptosis; Iron; Therapeutic target
MeSH: Humans; Cardiovascular Diseases; Ferroptosis; Iron; Trace Elements
From: Journal of Zhejiang University. Science. B 2024;25(1):1-22
CountryChina
Language:English
Abstract: Cardiovascular diseases (CVDs) are a leading factor driving mortality worldwide. Iron, an essential trace mineral, is important in numerous biological processes, and its role in CVDs has raised broad discussion for decades. Iron-mediated cell death, namely ferroptosis, has attracted much attention due to its critical role in cardiomyocyte damage and CVDs. Furthermore, ferritinophagy is the upstream mechanism that induces ferroptosis, and is closely related to CVDs. This review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy, and the regulatory pathways and molecular targets involved in ferritinophagy, and to determine their roles in CVDs. Furthermore, we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating CVDs. Collectively, this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.