HPCAL1 is a novel driver of autophagy-dependent ferroptosis.

Author: Liwen WANG ¹ ; Qin LI ¹ ; Huimei LIU ² ; Lanfang LI ³
Author Information

1. Institute of Pharmaceutical Pharmacology, School of Pharmacy, University of South China, Hengyang 421001, China.
2. Hengyang Medical School, University of South China, Hengyang 421001, China.
3. Institute of Pharmaceutical Pharmacology, School of Pharmacy, University of South China, Hengyang 421001, China. llanfang6@126.com.
Publication Type:Journal Article
MeSH: Ferroptosis; Cell Line, Tumor; Autophagy
From: Journal of Zhejiang University. Science. B 2023;24(11):1053-1056
CountryChina
Language:English
Abstract: 自噬是细胞内一种高度保守的生理过程，可通过溶酶体系统降解过量或受损的细胞器、有毒的蛋白聚集体和病原体等。最新研究表明，海马钙素样1（HPCAL1）可作为特异性自噬受体和铁死亡的正调节因子。HPCAL1可选择性降解钙粘素2（CDH2），加速脂质过氧化，促进癌细胞铁死亡。iHPCAL1是抑制HPCAL1的小分子化合物，可抑制Erastin诱导的肿瘤细胞铁死亡。此外，它还可以抑制铁死亡诱导的急性胰腺炎。本文通过对HPCAL1在铁死亡中的具体作用机制进行概述，为HPCAL1作为铁死亡相关疾病的潜在治疗靶点提供新思路和理论依据。