Application of interim PET-CT in first-line treatment decision-making for lymphoma.

Linlin Huang; Yi Zhao; Jingsong HE

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Application of interim PET-CT in first-line treatment decision-making for lymphoma.

Author: Linlin HUANG ¹ ; Yi ZHAO ² ; Jingsong HE ³
Author Information

1. Bone Marrow Transplantation Center, Department of Hematology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
2. Bone Marrow Transplantation Center, Department of Hematology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China. hejingsong@zju.edu.cn, zhaoyi999@zju.edu.cn.
3. Bone Marrow Transplantation Center, Department of Hematology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China. hejingsong@zju.edu.cn.
Publication Type:Journal Article
Keywords: Interim PET (iPET)‍-adapted therapy; Lymphoma; Positron emission tomography-computed tomography (PET-CT)
From: Journal of Zhejiang University. Science. B 2023;24(10):905-921
CountryChina
Language:English
Abstract: Recent advances in lymphoma treatment have significantly improved the survival of patients; however, the current approaches also have varying side effects. To overcome these, it is critical to implement individualized treatment according to the patient's condition. Therefore, the early identification of high-risk groups and targeted treatment are important strategies for prolonging the survival time and improving the quality of life of patients. Interim positron emission tomography-computed tomography (PET-CT) has a high prognostic value, which can reflect chemosensitivity and identify patients for whom treatment may fail under this regimen. To date, many prospective clinical studies on interim PET (iPET)‍-adapted therapy have been conducted. In this review, we focus on the treatment strategies entailed in these studies, as well as the means and timing of iPET assessment, with the aim of exploring the efficacy and existing issues regarding iPET-adapted treatment. It is expected that the improved use of PET-CT examination can facilitate treatment decision-making to identify precise treatment options.