Anti-migratory effects of Piper betle leaf aqueous extract on cancer cells and its microtubule targeting properties.

Mee Lee Looi; Alwyn Khai Howe Wong; Shelly Anne Gnapragasan; Anis Zafirah Japri; Aiysvariyah Rajedadram; Kar Yong Pin

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Anti-migratory effects of Piper betle leaf aqueous extract on cancer cells and its microtubule targeting properties.

Author: Mee Lee LOOI ¹ ; Alwyn Khai Howe WONG ² ; Shelly Anne GNAPRAGASAN ² ; Anis Zafirah JAPRI ² ; Aiysvariyah RAJEDADRAM ² ; Kar Yong PIN ³
Author Information

1. Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
2. School of Biosciences, Taylor's University, Lakeside Campus, Subang Jaya, Selangor Darul Ehsan 47500, Malaysia.
3. Forest Research Institute Malaysia, Kepong, Selangor Darul Ehsan 52109, Malaysia.
Publication Type:Journal Article
Keywords: Piper betle; Cell migration; Microtubules; Tubulin network
MeSH: Antineoplastic Agents, Phytogenic/pharmacology*; Cell Movement/drug effects*; HT29 Cells; Humans; Microtubules/drug effects*; Piper betle; Plant Extracts/pharmacology*; Plant Leaves
From: Journal of Zhejiang University. Science. B 2020;21(9):745-748
CountryChina
Language:English
Abstract: Piper betle (PB), also known as "betel" in Malay language, is a tropical Asian vine. PB leaves are commonly chewed by Asians along with betel quid. It contains phenols such as eugenol and hydroxychavicol along with chlorophyll, β-carotene, and vitamin C (Salehi et al., 2019). Extracts from PB leaves have various medicinal properties including anticancer, antioxidant, anti-inflammatory, and antibacterial effects (Salehi et al., 2019). Previous research has shown that PB induces cell cycle arrest at late S or G2/M phase and causes apoptosis at higher doses (Wu et al., 2014; Guha Majumdar and Subramanian, 2019). A combination of PB leaf extract has also been shown to enhance the cytotoxicity of the anticancer drug, 5-fluorouracil (5-FU), in cancer cells (Ng et al., 2014).