Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models.

Author: Hai-Qiong ZHENG ¹ ; Jia-Bing RONG ¹ ; Fei-Ming YE ¹ ; Yin-Chuan XU ¹ ; Hong S LU ² ; Jian-An WANG ¹
Author Information

1. Department of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
2. Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, USA.
Publication Type:Review
Keywords: Thoracic aortic dissection (TAD); β-Aminopropionitrile (BAPN); Angiotensin II (AngII); Mouse model; Hypertension
MeSH: Aminopropionitrile/toxicity*; Aortic Dissection/pathology*; Angiotensin II/toxicity*; Animals; Aortic Aneurysm, Thoracic/pathology*; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL
From: Journal of Zhejiang University. Science. B 2020;21(8):603-610
CountryChina
Language:English
Abstract: Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.