Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects.

Author: Cong-Ying SONG ¹ ; Ying-Ge XU ¹ ; Yuan-Qiang LU ¹
Author Information

1. Department of Emergency Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Publication Type:Review
Keywords: Tripterygium wilfordii Hook F; Anti-inflammation; Immunosuppression
MeSH: Animals; Anti-Inflammatory Agents/pharmacology*; Arthritis, Rheumatoid/drug therapy*; Drugs, Chinese Herbal/therapeutic use*; Humans; Immunosuppressive Agents/pharmacology*; Inflammation/drug therapy*; Inflammatory Bowel Diseases/drug therapy*; Medicine, Chinese Traditional; Pyroptosis/drug effects*; Tripterygium
From: Journal of Zhejiang University. Science. B 2020;21(4):280-290
CountryChina
Language:English
Abstract: Tripterygium wilfordii Hook F has significant anti-inflammatory and immunosuppressive properties and is widely used for treating autoimmune and inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, and kidney disease, especially in traditional Chinese medicine. The mechanisms underlying its effects may be diverse but they remain unclear, and its toxicity and side effects limit its wider clinical application. This review summarizes the clinical application of Tripterygium wilfordii Hook F in recent years, as well as the results of studies into its mechanisms and toxicity, to provide a reference for its future clinical application.