Analysis of nicotine-induced metabolic changes in Blakeslea trispora by GC-MS.

Yang Liu; You-ran Shao; Xiang-yu LI; Zhi-ming Wang; Li-rong Yang; Yu-zhou Zhang; Mian-bin WU; Jian-ming Yao

Return

Analysis of nicotine-induced metabolic changes in Blakeslea trispora by GC-MS.

Author: Yang LIU ¹ ; You-Ran SHAO ² ; Xiang-Yu LI ¹ ; Zhi-Ming WANG ³ ; Li-Rong YANG ² ; Yu-Zhou ZHANG ¹ ; Mian-Bin WU ² ; Jian-Ming YAO ¹
Author Information

1. Biotechnology Center, Institute of Plasma Physics and Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China.
2. Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
3. CABIO Bioengineering (Wuhan) Co. Ltd., Wuhan 436070, China.
Publication Type:Journal Article
Keywords: P2X7 receptor (P2X7R); Mechanical allodynia; Streptozotocin; Diabetic mice
MeSH: Citric Acid Cycle; Fermentation; Gas Chromatography-Mass Spectrometry/methods*; Lycopene/metabolism*; Mucorales/metabolism*; Nicotine/pharmacology*; beta Carotene/biosynthesis*
From: Journal of Zhejiang University. Science. B 2020;21(2):172-177
CountryChina
Language:English
Abstract: Blakeslea trispora is a natural source of carotenoids, including β-carotene and lycopene, which have industrial applications. Therefore, classical selective breeding techniques have been applied to generate strains with increased productivity, and microencapsulated β-carotene preparation has been used in food industry (Li et al., 2019). In B. trispora, lycopene is synthesized via the mevalonate pathway (Venkateshwaran et al., 2015). Lycopene cyclase, which is one of the key enzymes in this pathway, is a bifunctional enzyme that can catalyze the cyclization of lycopene to produce β-carotene and exhibit phytoene synthase activity (He et al., 2017).