- Author:
Cheng-Ming NI
1
;
Bing-Yu LING
2
;
Xiang XU
1
;
He-Ping SUN
3
;
Hui JIN
1
;
Yu-Qiu ZHANG
4
;
Hong CAO
4
;
Lan XU
1
Author Information
- Publication Type:Journal Article
- Keywords: P2X7 receptor (P2X7R); Mechanical allodynia; Streptozotocin; Diabetic mice
- MeSH: Animals; CX3C Chemokine Receptor 1/physiology*; Chemokine CX3CL1/physiology*; Diabetes Mellitus, Experimental/complications*; Diabetes Mellitus, Type 1/complications*; Diabetic Neuropathies/etiology*; Hyperalgesia/etiology*; Mice; Mice, Inbred C57BL; Spinal Cord/physiology*; Streptozocin/pharmacology*
- From: Journal of Zhejiang University. Science. B 2020;21(2):166-171
- CountryChina
- Language:English
- Abstract: Patients with diabetic peripheral neuropathy experience debilitating pain that significantly affects their quality of life (Abbott et al., 2011), by causing sleeping disorders, anxiety, and depression (Dermanovic Dobrota et al., 2014). The primary clinical manifestation of painful diabetic neuropathy (PDN) is mechanical hypersensitivity, also known as mechanical allodynia (MA) (Callaghan et al., 2012). MA's underlying mechanism remains poorly understood, and so far, based on symptomatic treatment, it has no effective therapy (Moore et al., 2014).