Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis.
- Author:
Wei ZHU
1
;
Bo-Lun ZHOU
1
;
Li-Juan RONG
1
;
Li YE
1
;
Hong-Juan XU
1
;
Yao ZHOU
1
;
Xue-Jun YAN
1
;
Wei-Dong LIU
1
;
Bin ZHU
1
;
Lei WANG
1
;
Xing-Jun JIANG
1
;
Cai-Ping REN
1
Author Information
- Publication Type:Review
- Keywords: Polypyrimidine tract-binding protein 1 (PTBP1); Alternative splicing; Glycolysis; M2 isoform of pyruvate kinase (PKM2); Cancer
- MeSH: Alternative Splicing; Carcinogenesis; Glycolysis; Heterogeneous-Nuclear Ribonucleoproteins/physiology*; Humans; MicroRNAs/physiology*; Neoplasms/pathology*; Polypyrimidine Tract-Binding Protein/physiology*; RNA, Long Noncoding/physiology*
- From: Journal of Zhejiang University. Science. B 2020;21(2):122-136
- CountryChina
- Language:English
- Abstract: Polypyrimidine tract-binding protein 1 (PTBP1) plays an essential role in splicing and is expressed in almost all cell types in humans, unlike the other proteins of the PTBP family. PTBP1 mediates several cellular processes in certain types of cells, including the growth and differentiation of neuronal cells and activation of immune cells. Its function is regulated by various molecules, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and RNA-binding proteins. PTBP1 plays roles in various diseases, particularly in some cancers, including colorectal cancer, renal cell cancer, breast cancer, and glioma. In cancers, it acts mainly as a regulator of glycolysis, apoptosis, proliferation, tumorigenesis, invasion, and migration. The role of PTBP1 in cancer has become a popular research topic in recent years, and this research has contributed greatly to the formulation of a useful therapeutic strategy for cancer. In this review, we summarize recent findings related to PTBP1 and discuss how it regulates the development of cancer cells.
