Integrated analysis of hypoxia-induced miR-210 signature as a potential prognostic biomarker of hepatocellular carcinoma: a study based on The Cancer Genome Atlas.

Author: Yi DAI ¹ ; Ji-Liang SHEN ² ; Xue-Yong ZHENG ² ; Tian-Yu LIN ² ; Hai-Tao YU ¹
Author Information

1. Zhejiang Provincial Key Laboratory of Laparoscopic Technology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
2. Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
Publication Type:Journal Article
Keywords: miR-210; The Cancer Genome Atlas (TCGA); Hepatocellular carcinoma (HCC); Hypoxia; prognostic biomarker
MeSH: Apoptosis Regulatory Proteins/physiology*; Biomarkers; Carcinoma, Hepatocellular/pathology*; Female; Genome; Humans; Hypoxia; Liver Neoplasms/pathology*; Male; MicroRNAs/analysis*; Neoplasm Staging; Prognosis; Repressor Proteins/physiology*
From: Journal of Zhejiang University. Science. B 2019;20(11):928-932
CountryChina
Language:English
Abstract: Hepatocellular carcinoma (HCC) is one of the most common types of liver cancer and is the second leading cause of cancer mortality with an estimated 745 500 deaths annually (Jemal et al., 2011). Although new therapeutic modalities including novel chemotherapeutic interventions and targeted therapy have been applied, the prognosis of HCC patients remains unsatisfactory due to the high incidence of intrahepatic and distal metastases (Siegel et al., 2018).