Alternative role of noncoding RNAs: coding and noncoding properties.

Gui-zhen Zheng; Wei LI; Zhi-yong Liu

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Alternative role of noncoding RNAs: coding and noncoding properties.

Author: Gui-Zhen ZHENG ¹ ; Wei LI ² ; Zhi-Yong LIU ³
Author Information

1. Department of Emergency Internal Medicine, Shanghai East Hospital, Tongji University, Shanghai 200120, China.
2. Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
3. Department of Laboratory Diagnostics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Publication Type:Review
Keywords: Non-coding RNA; Biological function; Micropeptides; Cellular stress
MeSH: Animals; Calcium/metabolism*; Humans; Open Reading Frames; Protein Biosynthesis; RNA, Messenger/genetics*; RNA, Untranslated/physiology*
From: Journal of Zhejiang University. Science. B 2019;20(11):920-927
CountryChina
Language:English
Abstract: Noncoding RNAs (ncRNAs) have played a critical role in cellular biological functions. Recently, some peptides or proteins originating from annotated ncRNAs were identified in organism development and various diseases. Here, we briefly review several novel peptides translated by annotated ncRNAs and related key functions. In addition, we summarize the potential mechanism of bifunctional ncRNAs and propose a specific "switch" triggering the transformation from the noncoding to the coding state under certain stimuli or cellular stress. The coding properties of ncRNAs and their peptide products may provide a novel horizon in proteomic research and can be regarded as a potential therapeutic target for the treatment of various diseases.