Estrogen modulation of visceral pain.

Author: Li-Hong SUN ¹ ; Wen-Xin ZHANG ¹ ; Qi XU ¹ ; Hui WU ¹ ; Cui-Cui JIAO ¹ ; Xin-Zhong CHEN ¹
Author Information

1. Department of Anesthesiology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Publication Type:Review
Keywords: Estrogen; Visceral pain; Hyperalgesia; Ovariectomization
MeSH: Animals; Estrogens/metabolism*; Female; Humans; Hyperalgesia/therapy*; Immune System; Male; Nociceptors; Ovariectomy; Pain Management; Pain Threshold; Sex Factors; Visceral Pain/therapy*
From: Journal of Zhejiang University. Science. B 2019;20(8):628-636
CountryChina
Language:English
Abstract: It is commonly accepted that females and males differ in their experience of pain. Gender differences have been found in the prevalence and severity of pain in both clinical and animal studies. Sex-related hormones are found to be involved in pain transmission and have critical effects on visceral pain sensitivity. Studies have pointed out the idea that serum estrogen is closely related to visceral nociceptive sensitivity. This review aims to summarize the literature relating to the role of estrogen in modulating visceral pain with emphasis on deciphering the potential central and peripheral mechanisms.