Genetic distribution and forensic evaluation of multiplex autosomal short tandem repeats in the Chinese Xinjiang Mongolian group.

Yuan-yuan Wei; Xiao-ye Jin; Qiong Lan; Wei Cui; Chong Chen; Ting-ting Kong; Yu-xin Guo; Jian-gang Chen; Bo-feng Zhu

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Genetic distribution and forensic evaluation of multiplex autosomal short tandem repeats in the Chinese Xinjiang Mongolian group.

Author: Yuan-Yuan WEI ¹ ; Xiao-Ye JIN ¹ ; Qiong LAN ² ; Wei CUI ¹ ; Chong CHEN ¹ ; Ting-Ting KONG ¹ ; Yu-Xin GUO ¹ ; Jian-Gang CHEN ³ ; Bo-Feng ZHU ¹
Author Information

1. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.
2. Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China.
3. Institute of Forensic Science, Ministry of Public Security, Beijing 100038, China.
Publication Type:Journal Article
Keywords: Xinjiang Mongolian group; Short tandem repeats (STRs); Forensic applications
MeSH: Alleles; Asian People/genetics*; China; DNA Fingerprinting; Databases, Genetic; Ethnicity/genetics*; Gene Frequency; Genetic Markers; Genetics, Population; Genome, Human; Humans; Linkage Disequilibrium; Microsatellite Repeats; Mongolia; Polymorphism, Genetic; Principal Component Analysis; Probability; Software
From: Journal of Zhejiang University. Science. B 2019;20(3):287-290
CountryChina
Language:English
Abstract: To further enrich the genetic data of the Chinese Xinjiang Mongolian group, the genetic distribution and forensic parameters of 19 autosomal short tandem repeats (STRs) were investigated. Altogether, 249 alleles were observed in these 19 STRs. The mean values of the polymorphism information content (PIC), match probability (MP), discrimination power (DP), and probability of exclusion (PE) for these 19 STRs were 0.7775, 0.0699, 0.9301, and 0.6085, respectively. Additionally, the cumulative DP and PE values obtained in the Mongolian group were 0.999 999 999 999 999 999 999 995 67 and 0.999 999 992 163, respectively. Furthermore, population genetic analysis of the Mongolian group and 20 published populations was conducted based on the population data of 15 overlapping STRs. Genetic distances indicated that the Mongolian group had closer genetic similarities with the Uyghur, Xibe, and other Chinese populations rather than the other continental populations. Multidimensional scaling analysis further revealed that the Mongolian group possessed similar genetic distributions as most Chinese populations. To sum it all up, these STRs could be used as an extremely efficient tool for forensic applications in the Xinjiang Mongolian group.