Oral administration of Lactobacillus rhamnosus GG to newborn piglets augments gut barrier function in pre-weaning piglets.

Yang Wang; Li Gong; Yan-ping WU; Zhi-wen Cui; Yong-qiang Wang; Yi Huang; Xiao-ping Zhang; Wei-fen LI

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Oral administration of Lactobacillus rhamnosus GG to newborn piglets augments gut barrier function in pre-weaning piglets.

Author: Yang WANG ¹ ; Li GONG ¹ ; Yan-Ping WU ¹ ; Zhi-Wen CUI ¹ ; Yong-Qiang WANG ² ; Yi HUANG ¹ ; Xiao-Ping ZHANG ³ ; Wei-Fen LI ¹
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1. Key Laboratory of Molecular Animal Nutrition and Feed Science, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University, Hangzhou 310058, China.
2. Department of Animal Sciences, Oregon State University, Corvallis, OR 97330, USA.
3. China National Bamboo Research Center, Key Laboratory of High Efficient Processing of Bamboo of Zhejiang Province, Hangzhou 310012, China.
Publication Type:Journal Article
Keywords: Lactobacillus rhamnosus; Gut microbiota; Intestinal physical barrier; Intestinal immunological barrier; Piglet
MeSH: Administration, Oral; Animals; Animals, Newborn; Cytokines/genetics*; Female; Gastrointestinal Microbiome; Immunity, Innate; Intestinal Mucosa/immunology*; Lacticaseibacillus rhamnosus; Male; Probiotics/administration & dosage*; Signal Transduction; Swine; Weaning
From: Journal of Zhejiang University. Science. B 2019;20(2):180-192
CountryChina
Language:English
Abstract: To understand the effects of Lactobacillus rhamnosus GG (ATCC 53103) on intestinal barrier function in pre-weaning piglets under normal conditions, twenty-four newborn littermate piglets were randomly divided into two groups. Piglets in the control group were orally administered with 2 mL 0.1 g/mL sterilized skim milk while the treatment group was administered the same volume of sterilized skim milk with the addition of viable L. rhamnosus at the 1st, 3rd, and 5th days after birth. The feeding trial was conducted for 25 d. Results showed that piglets in the L. rhamnosus group exhibited increased weaning weight and average daily weight gain, whereas diarrhea incidence was decreased. The bacterial abundance and composition of cecal contents, especially Firmicutes, Bacteroidetes, and Fusobacteria, were altered by probiotic treatment. In addition, L. rhamnosus increased the jejunal permeability and promoted the immunologic barrier through regulating antimicrobial peptides, cytokines, and chemokines via Toll-like receptors. Our findings indicate that oral administration of L. rhamnosus GG to newborn piglets is beneficial for intestinal health of pre-weaning piglets by improving the biological, physical, and immunologic barriers of intestinal mucosa.