Role of cytoplasmic lncRNAs in regulating cancer signaling pathways.

Pei-fen FU; Xin Zheng; Xiao Fan; Ai-fu Lin

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Role of cytoplasmic lncRNAs in regulating cancer signaling pathways.

Author: Pei-Fen FU ¹ ; Xin ZHENG ² ; Xiao FAN ² ; Ai-Fu LIN ¹
Author Information

1. The Breast Centre, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
2. MOE Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Publication Type:Review
Keywords: Long noncoding RNA (lncRNA); Cancer signaling; Cancer therapy; Biomarker
MeSH: Animals; Biomarkers, Tumor/metabolism*; Cytoplasm/metabolism*; Hippo Signaling Pathway; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism*; Neoplasms/metabolism*; Phosphatidylinositol 3-Kinases/metabolism*; Protein Serine-Threonine Kinases/metabolism*; Proto-Oncogene Proteins c-akt/metabolism*; RNA, Long Noncoding/metabolism*; Signal Transduction/genetics*
From: Journal of Zhejiang University. Science. B 2019;20(1):1-8
CountryChina
Language:English
Abstract: Cancer remains a serious healthcare problem despite significant improvements in early detection and treatment approaches in the past few decades. Novel biomarkers for diagnosis and therapeutic strategies are urgently needed. In recent years, long noncoding RNAs (lncRNAs) have been reported to be aberrantly expressed in tumors and show crosstalk with key cancer-related signaling pathways. In this review, we summarized the current progress of research on cytoplasmic lncRNAs and their roles in regulating cancer signaling and tumor progression, further characterization of which may lead to effective approaches for cancer prevention and therapy.