Effect of a combination of astaxanthin supplementation, heat stress, and intermittent reloading on satellite cells during disuse muscle atrophy.

Toshinori Yoshihara; Takao Sugiura; Nobuyuki Miyaji; Yuki Yamamoto; Tsubasa Shibaguchi; Ryo Kakigi; Hisashi Naito; Katsumasa Goto; Daijiro Ohmori; Toshitada Yoshioka

Return

Effect of a combination of astaxanthin supplementation, heat stress, and intermittent reloading on satellite cells during disuse muscle atrophy.

Author: Toshinori YOSHIHARA ¹ ; Takao SUGIURA ² ; Nobuyuki MIYAJI ³ ; Yuki YAMAMOTO ⁴ ; Tsubasa SHIBAGUCHI ⁵ ; Ryo KAKIGI ⁶ ; Hisashi NAITO ¹ ; Katsumasa GOTO ⁷ ; Daijiro OHMORI ⁸ ; Toshitada YOSHIOKA ⁹
Author Information

1. Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba 270-1695, Japan.
2. Faculty of Education, Yamaguchi University, Yamaguchi, Yamaguchi 753-8513, Japan.
3. Toyo Koso Kagaku Co. Ltd., Urayasu, Chiba 279-0041, Japan.
4. Institute of Health and Sports Science, Kurume University, Kurume, Fukuoka 839-8502, Japan.
5. Institute of Liberal Arts and Science, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan.
6. Faculty of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-0033, Japan.
7. Graduate School of Health Sciences, Toyohashi SOZO University, Toyohashi, Aichi 440-8511, Japan.
8. Department of Chemistry, School of Medicine, Juntendo University, Inzai, Chiba 270-1695, Japan.
9. Hirosaki Gakuin University, Hirosaki, Aomori 036-8577, Japan.
Publication Type:Journal Article
Keywords: Antioxidant astaxanthin; Disuse muscle atrophy; Heat stress; Satellite cell
MeSH: Animals; Body Weight; Dietary Supplements; Fibrinolytic Agents/pharmacology*; Heat-Shock Response; Hindlimb; Hot Temperature; Immunohistochemistry; Male; Muscle, Skeletal; Muscular Atrophy/drug therapy*; Oxidative Stress; Rats; Rats, Wistar; Satellite Cells, Skeletal Muscle/cytology*; Xanthophylls/pharmacology*
From: Journal of Zhejiang University. Science. B 2018;19(11):844-852
CountryChina
Language:English
Abstract: We examined the effect of a combination of astaxanthin (AX) supplementation, repeated heat stress, and intermittent reloading (IR) on satellite cells in unloaded rat soleus muscles. Forty-nine male Wistar rats (8-week-old) were divided into control, hind-limb unweighting (HU), IR during HU, IR with AX supplementation, IR with repeated heat stress (41.0-41.5 °C for 30 min), and IR with AX supplementation and repeated heat stress groups. After the experimental period, the antigravitational soleus muscle was analyzed using an immunohistochemical technique. Our results revealed that the combination of dietary AX supplementation and heat stress resulted in protection against disuse muscle atrophy in the soleus muscle. This protective effect may be partially due to a higher satellite cell number in the atrophied soleus muscle in the IR/AX/heat stress group compared with the numbers found in the other groups. We concluded that the combination treatment with dietary AX supplementation and repeated heat stress attenuates soleus muscle atrophy, in part by increasing the number of satellite cells.