An efficacy analysis of anti-vascular endothelial growth factor therapy for choroidal neovascularization secondary to multifocal choroiditis and comparison with wet age-related macular degeneration.
- Author:
Lei FENG
1
;
Jiang-Hua HU
1
;
Jie CHEN
2
;
Xin XIE
1
Author Information
- Publication Type:Journal Article
- Keywords: Wet age-related macular degeneration (AMD); Multifocal choroiditis (MFC); Juxtafoveal choroidal neovascularization (CNV); Anti-vascular endothelial growth factor (VEGF) therapy
- MeSH: Adult; Aged; Angiogenesis Inhibitors/therapeutic use*; Choroidal Neovascularization/drug therapy*; Female; Humans; Inflammation; Intravitreal Injections; Macular Degeneration/drug therapy*; Male; Middle Aged; Ranibizumab/therapeutic use*; Treatment Outcome; Vascular Endothelial Growth Factor A/antagonists & inhibitors*; Vision, Ocular; Wet Macular Degeneration/drug therapy*
- From: Journal of Zhejiang University. Science. B 2018;19(4):327-332
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To evaluate the effect of anti-vascular endothelial growth factor (VEGF) on juxtafoveal choroidal neovascularization (CNV) secondary to multifocal choroiditis (MFC) and wet age-related macular degeneration (AMD).
METHODS:In this retrospective, comparative study, 20 unique eyes with CNV were divided into two groups: 10 patients affected by MFC and 10 patients diagnosed with wet AMD. They all received local intravitreal (IVT) injections of ranibizumab, with 6 months of follow-up. Retreatment injections were performed based on findings suggestive of active neovascularization.
RESULTS:Significant improvements were observed in the juxtafoveal CNV lesions, and average central macular thickness decreased in both groups following the anti-VEGF therapy (P<0.05). The average number of injections used in MFC patients was 1.6, while three injections on average were used in wet AMD patients (Z=-2.844, P=0.009). Best-corrected visual acuity was significantly improved in MFC patients after anti-VEGF therapy (P<0.05), and there was no significant difference in wet AMD patients between before anti-VEGF therapy and 6 months later (P>0.05).
CONCLUSIONS:IVT ranibizumab resulted in good clinical outcomes for juxtafoveal CNV secondary to MFC and wet AMD, but the average number of injections used in MFC was fewer than that used in wet AMD over a 6-month observation period. Compared with the wet AMD group, visual acuity was obviously improved in the MFC group at 6 months.
