Activity of metalloproteinases and adiponectin in obese patients-a possible factor of incisional hernias after bariatric procedures.

Wojciech SZCZĘSNY; Magdalena KULIGOWSKA-PRUSIŃSKA; Stanisław DĄBROWIECKI; Jakub SZMYTKOWSKI; Adrian REŚLIŃSKI; Maciej SŁUPSKI

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Activity of metalloproteinases and adiponectin in obese patients-a possible factor of incisional hernias after bariatric procedures.

Author: Wojciech SZCZĘSNY ¹ ; Magdalena KULIGOWSKA-PRUSIŃSKA ¹ ; Stanisław DĄBROWIECKI ¹ ; Jakub SZMYTKOWSKI ¹ ; Adrian REŚLIŃSKI ¹ ; Maciej SŁUPSKI ¹
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1. Ludwik Rydygier College of Medicine in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.
Publication Type:Journal Article
Keywords: Metalloproteinase; Adiponectin; Obesity; Incisional hernia
MeSH: Adiponectin/blood*; Adult; Aged; Bariatric Surgery; Body Mass Index; Female; Humans; Incisional Hernia/blood*; Male; Matrix Metalloproteinase 13/blood*; Matrix Metalloproteinase 2/blood*; Matrix Metalloproteinase 9/blood*; Metalloproteases/blood*; Middle Aged; Obesity, Morbid/surgery*; ROC Curve; Risk Factors; Wound Healing; Young Adult
From: Journal of Zhejiang University. Science. B 2018;19(1):65-70
CountryChina
Language:English
Abstract: PURPOSE:Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and non-overweight controls.
MATERIALS AND METHODS:The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m², n=40) and II (BMI<25 kg/m², n=30). Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay (ELISA).
RESULTS:A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group.
CONCLUSIONS:The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.