Efficacy of Chinese Herbal Medicines on Pregnancy Outcomes in Patients with Endometriosis in Long-Term Management: A Multicenter Retrospective Cohort Study.
10.1007/s11655-023-3736-z
- Author:
Xin-Chun YANG
1
;
Yong LIU
1
;
Wei-Wei SUN
1
;
Guang SHI
1
;
Ying WU
2
;
Cai XU
3
;
Qing-Wei MENG
4
;
Zeng-Ping HAO
5
;
Qian HAN
2
;
Rui-Hua ZHAO
6
Author Information
1. Department of Gynecology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
2. Department of Traditional Chinese Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China.
3. Department of Gynecology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China.
4. Department of Obstetrics and Gynecology, Beijing Hospital, Beijing, 100730, China.
5. Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
6. Department of Gynecology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China. rhzh801@126.com.
- Publication Type:Journal Article
- Keywords:
Chinese herbal medicine;
endometriosis;
long-term management;
multivariate analysis;
pregnancy;
retrospective cohort study
- MeSH:
Pregnancy;
Female;
Humans;
Adult;
Pregnancy Outcome;
Endometriosis/surgery*;
Retrospective Studies;
Cohort Studies;
Adenomyosis;
Gonadotropin-Releasing Hormone;
Plant Extracts;
Fertilization in Vitro
- From:
Chinese journal of integrative medicine
2023;29(11):971-979
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To analyze the factors related to pregnancy of endometriosis and whether Chinese herbal medicines (CHMs) can improve pregnancy outcomes in patients with endometriosis in long-term management.
METHODS:This multicenter cohort study retrospectively analyzed the clinical data of endometriosis patients with fertility needs from January 2019 to November 2019. A total of 252 patients with endometriosis from 5 level-III Grade A hospitals in Beijing were included in this study. Univariate and multivariate logistic regression analysis were performed for the relevant factors. The propensity score matching (PSM) function of SPSS software was used to match the CHMs group with the non-CHMs group. The pregnancy rate and live birth rate were analyzed.
RESULTS:The results of univariate analysis showed that age, disease course, presence of infertility, presence of adenomyosis, time after surgery or use of gonadotropin-releasing hormone agonist (GnRH-a), use of CHMs and follow-up time were influencing factors of pregnancy in endometriosis patients (P<0.05). The results of multivariate analysis showed that age, presence of adenomyosis, time after surgery or use of GnRH-a, use of CHMs and follow-up time were independent factors affecting pregnancy in endometriosis patients, among which, age ⩾35 years old, presence of adenomyosis and follow-up time >6 months were independent risk factors (OR=0.445, 0.348, 0.140, respectively, P<0.05), time after surgery or use of GnRH-a ⩽6 months and use of CHMs were independent protective factors (OR=3.839, 3.842, respectively, P<0.05). After PSM, 99 pairs of two groups were matched successfully. The pregnancy rate of the CHMs group was higher than that of the non-CHMs group [55.56% (55/99) vs. 36.36% (36/99), P<0.05]. The live birth rate of the CHMs group was higher than that of the non-CHMs group [49.49% (49/99) vs. 35.35% (35/99), P<0.05].
CONCLUSION:CHMs can effectively improve clinical pregnancy rate and live birth rate of patients with endometriosis in the chronic disease management.
